- Last edited on June 1, 2023
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cl:paraneoplastic-disorders [on June 1, 2023] psychdb [Psychiatric] |
cl:paraneoplastic-disorders [on June 1, 2023] psychdb [Psychiatric] |
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| **Paraneoplastic disorders** can lead to severe psychiatric and behavioural symptoms. Rapid identification is required to ensure correct treatment and management to avoid misdiagnosis of a paraneoplastic neurologic disorder. Paraneoplastic neurological syndromes (PNS) are the immune-mediated effects of a remote cancer and are characterized by an autoantibody response against the antigens expressed by the tumour. | **Paraneoplastic disorders** can lead to severe psychiatric and behavioural symptoms. Rapid identification is required to ensure correct treatment and management to avoid misdiagnosis of a paraneoplastic neurologic disorder. Paraneoplastic neurological syndromes (PNS) are the immune-mediated effects of a remote cancer and are characterized by an autoantibody response against the antigens expressed by the tumour. | ||
| - | ===== Psychiatric ===== | + | ===== Autoantibodies ===== |
| - | This autoantibody response can be psychiatric in nature, and includes: | + | The autoantibody response can be psychiatric in nature, and includes: |
| - | * [[cl:0-autoimmune-encephalitis:anti-nmda-receptor|NMDAR-antibody encephalitis]] | + | * **[[cl:0-autoimmune-encephalitis:anti-nmda-receptor|NMDAR-antibody encephalitis]]**, associated with ovarian teratomas in younger women |
| - | * Ophelia syndrome, associated with surface- directed mGluR5-antibodies (seen in patients with Hodgkin’s lymphoma) | + | * Ophelia syndrome, associated with surface-directed **mGluR5-antibodies**, seen in patients with Hodgkin’s lymphoma |
| + | * **Anti-neuronal nuclear antibody-1 (ANNA-1)**, also known as **Hu** paraneoplastic encephalomyelitis, associated with small cell lung cancer in 75% of cases (other tumours include lung, prostate, breast, bladder, GI tract, ovary, neuroendocrine, unknown origin), most commonly in men. | ||
| + | * **AMPA receptor antibodies**, associated with lung, breast, thymus, ovarian tumours. | ||
| ===== Paraneoplastic Limbic Encephalitis ===== | ===== Paraneoplastic Limbic Encephalitis ===== | ||
| <alert icon="fa fa-arrow-circle-right fa-lg fa-fw" type="success">See main article: **[[cl:0-autoimmune-encephalitis:home]]**</alert> | <alert icon="fa fa-arrow-circle-right fa-lg fa-fw" type="success">See main article: **[[cl:0-autoimmune-encephalitis:home]]**</alert> | ||